Monday, April 29, 2013

Turtle genome analysis sheds light on turtle ancestry and shell evolution

Apr. 28, 2013 ? From which ancestors have turtles evolved? How did they get their shell? New data provided by the Joint International Turtle Genome Consortium, led by researchers from RIKEN in Japan, BGI in China, and the Wellcome Trust Sanger Institute in the UK provides evidence that turtles are not primitive reptiles but belong to a sister group of birds and crocodiles. The work also sheds light on the evolution of the turtle's intriguing morphology and reveals that the turtle's shell evolved by recruiting genetic information encoding for the limbs.

Turtles are often described as evolutionary monsters, with a unique body plan and a shell that is considered to be one of the most intriguing structures in the animal kingdom.

"Turtles are interesting because they offer an exceptional case to understand the big evolutionary changes that occurred in vertebrate history," explains Dr. Naoki Irie, from the RIKEN Center for Developmental Biology, who led the study.

Using next-generation DNA sequencers, the researchers from 9 international institutions have decoded the genome of the green sea turtle and Chinese soft-shell turtle and studied the expression of genetic information in the developing turtle.

Their results published in Nature Genetics show that turtles are not primitive reptiles as previously thought, but are related to the group comprising birds and crocodilians, which also includes extinct dinosaurs. Based on genomic information, the researchers predict that turtles must have split from this group around 250 million years ago, during one of the largest extinction events ever to take place on this planet.

"We expect that this research will motivate further work to elucidate the possible causal connection between these events," says Dr. Irie.

The study also reveals that despite their unique anatomy, turtles follow the basic embryonic pattern during development. Rather than developing directly into a turtle-specific body shape with a shell, they first establish the vertebrates' basic body plan and then enter a turtle-specific development phase. During this late specialization phase, the group found traces of limb-related gene expression in the embryonic shell, which indicates that the turtle shell evolved by recruiting part of the genetic program used for the limbs.

"The work not only provides insight into how turtles evolved, but also gives hints as to how the vertebrate developmental programs can be changed to produce major evolutionary novelties." explains Dr. Irie.

Another unexpected finding of the study was that turtles possess a large number of olfactory receptors and must therefore have the ability to smell a wide variety of substances. The researchers identified more than 1000 olfactory receptors in the soft-shell turtle, which is one of the largest numbers ever to be found in a non-mammalian vertebrate.

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Story Source:

The above story is reprinted from materials provided by RIKEN, via AlphaGalileo.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Zhuo Wang, Juan Pascual-Anaya, Amonida Zadissa, Wenqi Li, Yoshihito Niimura, Zhiyong Huang, Chunyi Li, Simon White, Zhiqiang Xiong, Dongming Fang, Bo Wang, Yao Ming, Yan Chen, Yuan Zheng, Shigehiro Kuraku, Miguel Pignatelli, Javier Herrero, Kathryn Beal, Masafumi Nozawa, Qiye Li, Juan Wang, Hongyan Zhang, Lili Yu, Shuji Shigenobu, Junyi Wang, Jiannan Liu, Paul Flicek, Steve Searle, Jun Wang, Shigeru Kuratani, Ye Yin, Bronwen Aken, Guojie Zhang, Naoki Irie. The draft genomes of soft-shell turtle and green sea turtle yield insights into the development and evolution of the turtle-specific body plan. Nature Genetics, 2013; DOI: 10.1038/ng.2615

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_environment/~3/8zHOVHrvis0/130428144848.htm

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Mapping of cancer cell fuel pumps paves the way for new drugs

Apr. 28, 2013 ? For the first time, researchers at Karolinska Institutet in Sweden have managed to obtain detailed images of the way in which the transport protein GLUT transports sugars into cells. Since tumours are highly dependent on the transportation of nutrients in order to be able to grow rapidly, the researchers are hoping that the study published in the scientific magazine Nature Structural & Molecular Biology will form the basis for new strategies to fight cancer cells.

In order to be able to fuel their rapid growth, cancer tumours depend on transporter proteins to work at high speed to introduce sugars and other nutrients that are required for the cell's metabolism. One possible treatment strategy would therefore be to block some of the transporters in the cell membrane which operate as fuel pumps, thus starving out and killing the cancer cells.

One important group of membrane transporters is the GLUT family, which introduces glucose and other sugars into the cell. Glucose is one of the most important energy sources for cancer cells and GLUT transporters have been shown to play a key role in tumour growth in many different types of cancer.

In the current study, researchers from Karolinska Institutet have performed a detailed study of the way in which suger transport is executed by the protein XylE, from the Escherichia colibacterium, whose function and structure is very similar to GLUT transporters in humans. For the first time, the researchers have described the way in which the protein's structure changes between two different conformations when it binds and transports a sugar molecule.

"In showing details of the molecular structure of the region that bind the sugar, our study opens up the opportunities to more efficiently develop new substances that may inhibit GLUT transporters," says P?r Nordlund at the Department of Medical Biochemistry and Biophysics, one of the researchers behind the study. "Information on the structure of the transport protein facilitates the development of better drugs in a shorter time. Such GLUT inhibitors could potentially be used to treat cancer in the future."

The study may be of significance not just to cancer research but also in the field of diabetes. GLUT plays a key role in diabetes since insulin works by activating the uptake of glucose from the blood by means of GLUT transporters in the cell membrane.

GLUT and the studied XylE transporter belong to the very large group of metabolite transporters called the Major Facilitator Superfamily (MFS), which is important in many diseases and for the uptake of medicines in cells.

"Many aspects concerning molecular mechanisms for the function of GLUT transporters are probably common to many members of the MFS family, which are involved in a broad spectrum of diseases in addition to cancer and diabetes," says P?r Nordlund.

As well as membrane transporters, which have undergone in-depth analysis in the current study, many different membrane proteins pass through the surface membrane of the cells. Their significance to the cell function and the development of drugs has been noted before, not least through the Nobel Prizes that were awarded to researchers who used mechanistic and structural studies to map the function of two other major membrane protein families, G-protein-coupled receptors and ion channels.

The current study has been financed by grants from the Swedish Research Council, the Swedish Cancer Society, the European Molecular Biology Organization (EMBO) and The Danish Council for Independent Research.

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Story Source:

The above story is reprinted from materials provided by Karolinska Institutet, via AlphaGalileo.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Esben M Quistgaard, Christian L?w, Per Moberg, Lionel Tr?saugues, P?r Nordlund. Structural basis for substrate transport in the GLUT-homology family of monosaccharide transporters. Nature Structural & Molecular Biology, 2013; DOI: 10.1038/nsmb.2569

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/YpfcBJy_z0w/130428144853.htm

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Sunday, April 28, 2013

Rolling Stones To Play Echo Park's Echoplex In Secret Show - Echo Park-Silver-Lake, CA Patch

Rolling Stones To Play Echo Park's Echoplex In Secret Show - Echo Park-Silver-Lake, CA Patch

echopark.patch.com:

This is not a joke.

The Rolling Stones will play the Echoplex in Echo Park Saturday night. Owner Mitchell Frank says the show will begin at 9 p.m., with access extremely limited. The LA Weekly says capacity is 700.

Read the whole story at echopark.patch.com

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    Source: http://www.huffingtonpost.com/2013/04/27/rolling-stones-to-play-ec_n_3171829.html

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    Make Significantly more Capital In Affiliate Advertising and ...

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    Source: http://www.articlessquad.com/make-significantly-more-capital-in-affiliate-advertising-and-marketing/?utm_source=rss&utm_medium=rss&utm_campaign=make-significantly-more-capital-in-affiliate-advertising-and-marketing

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    Friday, April 26, 2013

    Local Filmmakers' A Measure of the Sin Tonight at Belcourt | Country ...

    Local Filmmakers' A Measure of the Sin Tonight at Belcourt

    Posted by Jim Ridley on Thu, Apr 25, 2013 at 2:18 PM

    A MEASURE OF THE SIN Trailer from Jeff Wedding on Vimeo.

    You've probably seen Katie Groshong and Jeff Wedding at the Nashville Film Festival this week, talking up their feature A Measure of the Sin. To see it, though, you'll need to duck out of NaFF (or at least slip out of the closing-night gala early) and head over to The Belcourt tonight at 10 p.m., when the movie makes its local premiere.

    Here's the IMDB synopsis:

    Every childhood is normal to the child who lives it. For Meredith that means an enchanted seclusion that is shattered when she is deprived of her mother. Desperate and alone, Meredith must join a household with other women and their children, a sinister man who controls every facet of her existence, and a vicious bear that only she can see. As life in this world becomes increasingly strange and frightening, Meredith realizes that she must flee, even though she fears she has not learned enough to survive on her own.

    Actor-producer (and former Belmont music student) Groshong and director-writer-cinematographer-editor Wedding first teamed on the 2004 thriller Blind. She's received extra attention this week at NaFF for her role in Chad Crawford Kinkle's horror film Jug Face, which earned an added second screening tonight at 6. A Measure of the Sin was co-written by Kristy Nielsen and co-stars a number of familiar local faces, including Starina Johnson and Ryan Jackson. Admission tonight is $10.

    Tags: A Measure of the Sin, Katie Groshong, Jeff Wedding, Jug Face, Blind, Belcourt, Chad Crawford Kinkle, NaFF, Nashville Film Festival, Video

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    Thursday, April 25, 2013

    Boston victims face huge bills; donations pour in

    Cost of amputating a leg? At least $20,000. Cost of an artificial leg? More than $50,000 for the most high-tech models. Cost of an amputee's rehab? Often tens of thousands of dollars more.

    These are just a fraction of the medical expenses victims of the Boston Marathon bombing will face.

    The mammoth price tag is probably not what patients are focusing on as they begin the long healing process. But friends and strangers are already setting up fundraisers and online crowd-funding sites, and a huge Boston city fund has already collected more than $23 million in individual and corporate donations.

    No one knows yet if those donations ? plus health insurance, hospital charity funds and other sources ? will be enough to cover the bills. Few will even hazard a guess as to what the total medical bill will be for a tragedy that killed three people and wounded more than 270. At least 15 people lost limbs, and other wounds include head injuries and tissue torn apart by shrapnel.

    Health insurance, as practically anyone who has ever gotten hurt or sick knows, does not always cover all costs. In the case of artificial limbs, for example, some insurance companies pay for a basic model but not a computerized one with sophisticated, lifelike joints.

    Rose Bissonnette, founder of the New England Amputee Association, said that the moment she heard about the bombings, she knew immediately that her organization's services would be needed. The advocacy group helps amputees navigate things such as insurance coverage for artificial limbs.

    Bissonnette shared one group member's struggle to get coverage for artificial arms as an example of the red tape some bombing victims could face. The woman "got a call from the insurance company and the person on the other end said, 'How long are you going to need the prosthetic hands?'" Bissonnette recalled.

    Bissonnette herself was in a horrific car crash 16 years ago that left her with injuries similar to those facing the Boston victims. Her mangled lower left leg had to be amputated and her right ankle was partially severed. Her five-month hospital stay cost more than $250,000. Health insurance covered all her treatment, rehab and her prosthesis.

    Health economist Ted Miller noted that treating just one traumatic brain injury can cost millions of dollars, and at least one survivor has that kind of injury. He also pointed out that the medical costs will include treating anxiety and post-traumatic stress ? "an issue for a whole lot more people than just people who suffered physical injuries," he said.

    Adding to the tragedy's toll will be lost wages for those unable to work, including two Massachusetts brothers who each lost a leg, Miller said. They had been roofers but may have to find a new line of work.

    Many survivors will also need help with expenses beyond immediate health care, including things like modifying cars for those who lost limbs or remodeling homes to accommodate wheelchairs.

    Many survivors live in Massachusetts, a state that requires residents to have health insurance, "which should cover most of their required treatment," said Amie Breton, spokeswoman for Massachusetts' consumer affairs office. "The total cost of that treatment is impossible to calculate at this early stage."

    Amputees may face the steepest costs, and artificial legs are the costliest. They range from about $7,200 for a basic below-the-knee model to as much as $90,000 for a high-tech microprocessor-controlled full leg, said Dr. Terrence Sheehan, chief medical officer for Adventist Rehabilitation Hospital in Rockville, Md., and medical director of the Amputee Coalition, a national advocacy group.

    Legs need to be replaced every few years, or more often for very active users or those who gain or lose weight. Limb sockets need to be replaced even more often and also cost thousands of dollars each, Sheehan said.

    Massachusetts is among about 20 states that require health insurers to pay for prosthetic limbs, but many plans don't cover 100 percent of those costs, Sheehan said. "Most are skimpy beyond basic prosthetics and they have not caught up with current available technology," he said.

    "The insurer will use terminology such as 'not medically necessary'" to deny computerized feet or knees that can often make the patient better able to function and more comfortable and safe, Sheehan said.

    Some insurers may be willing to make exceptions for the Boston blast survivors.

    "We will work to ensure that financial issues/hardship will not pose a barrier to the care that affected members' need," said Sharon Torgerson, spokeswoman for Blue Cross and Blue Shield of Massachusetts, one of the state's largest health insurers.

    Harvard Pilgrim Health Care, another big insurer, is changing its policy and will pay for some of the more expensive bionic limbs when there is a demonstrated need, said Dr. Michael Sherman, chief medical officer. He said that 15 blast survivors admitted to hospitals are Harvard Pilgrim customers and that the insurance company is discussing "whether we might absorb some of the copays and deductibles."

    "This is a terrorist act, and our only thought here is about providing support," he said.

    The 26 hospitals that have treated bombing victims have charity funds that will cover some of the costs, said Tim Gens, executive vice president of the Massachusetts Hospital Association. Some injured residents may be eligible for Massachusetts' public health funds for the uninsured or underinsured. People with huge medical bills they can't afford are eligible, regardless of income.

    Gens said hospitals are still focused on treating survivors, not on costs.

    "It's an extraordinary shock to so many individuals. The hospitals are working very hard to make sure that each family gets the support they need. Billing is not an issue they're addressing right now," Gens said.

    At Massachusetts General Hospital, where 31 victims have gotten treatment, chief financial officer Sally Mason Boemer said bills "create a lot of stress. Our assumption is there will be sources we can tap through fundraising." Boemer added: "Now is not the time to add additional stress to patients."

    Bombings survivor Heather Abbott said Thursday she has already gotten offers of help to pay for an artificial leg. The 38-year-old Newport, R.I., woman was waiting in line to get into a crowded bar when the bombs went off.

    "I felt like my foot was on fire. I knew I couldn't stand up," she recalled from her hospital bed. Surgeons amputated her left leg below the knee.

    A big chunk of charity money for survivors will come from One Fund Boston, established by Boston's mayor and Massachusetts Gov. Deval Patrick.

    The fund has gotten more than $20 million in donations. Determining who gets what is still being worked out, but victims' insurance status and place of residence won't be a factor, said Kenneth Feinberg, the fund administrator. He oversaw the 9/11 compensation fund during its first three years, distributing more than $7 billion to 5,300 families and victims.

    Grass-roots fundraising efforts include online funds set up by friends and relatives of the victims.

    Those victims include Roseann Sdoia, a Boston woman who was near the marathon finish line when the blasts occurred. Sdoia was hit by shrapnel, fire and a tree that became a projectile and injured her left leg, the funding site says. Her right leg had to be amputated above the knee. After several operations, Sdoia has started rehab.

    "She is a fighter and her attitude is phenomenal," said her friend and former sorority sister, Christine Hart, who set up the site. More than $270,000 has been raised for Sdoia so far, money that may help pay for an artificial leg, transportation to and from rehab, and modifications to her car or home, Hart said.

    The donations will help make sure "that finances are not part of the burden" she has to bear, Hart said.

    Other funds have been set up in communities like Stoneham, a Boston suburb that counts at least five current or former residents among the victims. A Stoneham Strong fundraising event is set for Friday evening, with participants asked to circle the high school track to show support for the marathon victims. Hundreds are expected, said organizer Shelly MacNeill.

    "The outpouring has been unbelievable," she said.

    ___

    AP Medical Writer Carla K. Johnson contributed to this report.

    ___

    Donations: http://www.onefundboston.org; http://www.gofundme.com/BelieveinBoston

    ____

    AP Medical Writer Lindsey Tanner can be reached at http://www.twitter.com/LindseyTanner

    Source: http://news.yahoo.com/boston-victims-face-huge-bills-donations-pour-174957328.html

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    False tweet sinks stock market. Is anyone checking this stuff?

    Stock markets tanked briefly (and then recovered) after the AP Twitter account was hacked and falsely announced a White House bombing. An array of new firms verify social media information to make sure clients aren't fooled.

    By Gloria Goodale,?Staff writer / April 23, 2013

    The White House was not bombed Tuesday, despite a fake tweet from AP to the contrary. These police were part of stepped up security Sunday in the wake of the Boston bombings.

    Jonathan Ernst/Reuters

    Enlarge

    Within 60 seconds of the Associated Press tweeting that the White House had been bombed ? a tweet that sent stock markets into a tailspin ? subscribers to Storyful knew it was a hoax.

    Skip to next paragraph

    ' + google_ads[0].line2 + '
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    '; } else if (google_ads.length > 1) { ad_unit += ''; } } document.getElementById("ad_unit").innerHTML += ad_unit; google_adnum += google_ads.length; return; } var google_adnum = 0; google_ad_client = "pub-6743622525202572"; google_ad_output = 'js'; google_max_num_ads = '1'; google_feedback = "on"; google_ad_type = "text"; google_adtest = "on"; google_image_size = '230x105'; google_skip = '0'; // -->

    The AP Twitter feed, it turns out, had been hacked, and stock markets quickly recovered. But the incident highlighted why Storyful exists. In a social media world gone mad, it is one of a handful of new companies trying to fill the growing need for some form of social media information verification.

    That need has been abundantly apparent during the past week. While law enforcement in the Boston bombing case called for the community to send photos, videos, and ideas, the response on social media included reams of raw information ? much of it false ? and half-baked theories. The family of a missing Brown University student had to refute false claims that he was involved.

    At times, the news media were drawn into the spiral of social media of misinformation, and that is what Storyful hopes to remedy. Billed as the first news agency for the social media age, this global enterprise of some 35 professionals ? many refugees from media such as CNN ? scans social media to alert clients about news before even local wires, TV, or radio have picked it up. It then cross-checks the information to verify sources.

    As social media becomes a greater part of the news media landscape, Storyful is just the sort of venture that could help each improve the other.

    ?We need both social and traditional journalism in our current age ? not one versus the other, not one or the other, but both,? says Paul Levinson, a professor of media studies at Fordham University in New York and author of ?New New Media,? via e-mail. ?Storyful looks like a significant step forward in bridging this gap.?

    Storyful may be the most full-service provider in this growing space, providing not just verification but alerts and help with managing rights and usage. Based in Dublin, Ireland, but with staff in Asia, Europe, and the US, Storyful now boasts a roster of major news outlets from Bloomberg News to The New York Times.

    Source: http://rss.csmonitor.com/~r/feeds/csm/~3/0K27qw5omXc/False-tweet-sinks-stock-market.-Is-anyone-checking-this-stuff

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    Rye Brook Public Hearing on Reckson Ice Proposal Tonight ...

    The Rye Brook Village Board will hold a public hearing on the Reckson Ice rink proposal, specifically on an application for approval of a special permit and amended site plan for Reckson Operating Partnership, L.P. at 1100 King Street.

    At the last public hearing in January, many residents spoke against the plan while a few spoke in favor of the ice arena.

    Rye Brook and Greenwich residents expressed deep concern over the traffic impact the 140,000 square-foot arena would have on King Street and on the surrounding neighborhoods. Other issues raised were concerns about hockey players and fans partying and drinking on site, noise, space for emergency vehicles, the watershed and environment, and preserving the current quality of life in Rye. Read more on the first public hearing here.

    Since then, the developers have submitted a revised building plan, dated April 13, and a 395-page traffic impact study update, dated April 11. You can find all those documents here.

    The public hearing will be at Rye Brook village hall at 7:30 p.m.?

    --

    What do you think of the Reckson proposal? Tell us in the comments.?

    Source: http://harrison.patch.com/articles/rye-brook-public-hearing-on-reckson-ice-proposal-tonight

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    Wednesday, April 24, 2013

    Hubble brings faraway comet into view

    Wednesday, April 24, 2013

    The NASA Hubble Space Telescope has given astronomers their clearest view yet of Comet ISON, a newly-discovered sun grazer comet that may light up the sky later this year, or come so close to the Sun that it disintegrates. A University of Maryland-led research team is closely following ISON, which offers a rare opportunity to witness a comet's evolution as it makes its first-ever journey through the inner solar system.

    Like all comets, ISON is a "dirty snowball" ? a clump of frozen gases mixed with dust, formed in a distant reach of the solar system, traveling on an orbit influenced by the gravitational pull of the Sun and its planets. ISON's orbit will bring it to a perihelion, or maximum approach to the Sun, of 700,000 miles on November 28, said Maryland assistant research scientist Michael S. Kelley.

    This image was made on April 10, when ISON was some 386 million miles from the Sun ? slightly closer to the Sun than the planet Jupiter. Comets become more active as they near the inner solar system, where the Sun's heat evaporates their ices into jets of gases and dust. But even at this great distance ISON is already active, with a strong jet blasting dust particles off its nucleus. As these dust particles shimmer in reflected sunlight, a portion of the comet's tail becomes visible in the Hubble image.

    Next week while the Hubble still has the comet in view, the Maryland team will use the space telescope to gather information about ISON's gases.

    "We want to look for the ratio of the three dominant ices, water, frozen carbon monoxide, and frozen carbon dioxide, or dry ice," said Maryland astronomy Prof. Michael A'Hearn. "That can tell us the temperature at which the comet formed, and with that temperature, we can then say where in the solar system it formed."

    The Maryland team will use both the Hubble Space Telescope and the instruments on the Deep Impact space craft to continue to follow ISON as it travels toward its November close up (perihelion) with the sun.

    ###

    University of Maryland: http://www.newsdesk.umd.edu/

    Thanks to University of Maryland for this article.

    This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

    This press release has been viewed 21 time(s).

    Source: http://www.labspaces.net/127887/Hubble_brings_faraway_comet_into_view

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    NM slaughterhouse ground zero in horse debate

    ROSWELL, N.M. (AP) ? About five miles from this southeastern New Mexico town's famed UFO museum, tucked between dairy farms, is a nondescript metal building that could be home to any number of small agricultural businesses.

    But Valley Meat Co. is no longer just another agricultural business. It's a former cattle slaughterhouse whose kill floor has been redesigned for horses to be led in one at a time, secured in a huge metal chute, shot in the head, then processed into meat for shipment overseas.

    It's also ground zero for an emotional, national debate over a return to domestic horse slaughter that has divided horse rescue and animal humane groups, ranchers, politicians and Indian tribes.

    At issue is whether horses are livestock or pets, and whether it is more humane to slaughter them domestically than to ship tens of thousands of neglected, unwanted and wild horses thousands of miles to be slaughtered in Mexico or Canada.

    Front and center of the debate is Rick De Los Santos, who along with his wife, Sarah, has for more than two decades worked this small slaughterhouse, taking in mostly cows that were too old or sick to travel with larger herds to the bigger slaughterhouses for production.

    Now, with cattle herds shrinking amid an ongoing drought, De Los Santos says he and his wife are just trying to transform their business and make enough money to retire by slaughtering domestically some of the thousands of horses that he says travel through the state every month on their way to what are oftentimes less humane and less regulated plants south of the border.

    "They are being slaughtered anyway. We thought, well, we will slaughter them here and provide jobs for the economy," De Los Santos said.

    Instead, Valley Meat has been ensnarled in a yearlong political drama that has left the plant idle and its owners the target of vandalism and death threats ? warnings that increased after humane groups found a video a now-former plant worker posted of himself cursing at animal activists, then shooting one of his own horses to eat.

    "People are saying, 'We will slit your throat in your sleep. We hope you die. We hope your kids die,'" De Los Santos said. "Sometimes it's scary. ... And it's all for a horse."

    Indeed, voice mails left on the company's answering machine spew hate and wishes for violence upon the family.

    "I hope you burn in hell," said one irate woman who called repeatedly, saying, "You better pack your (expletive) bags (expletive) and get out of there because that place is finished."

    The couple have hired security and turned over phone records to federal authorities. They are, nevertheless, surprisingly candid about their plans, offering media access to the 7,200-square-foot slaughterhouse with one kill floor and two processing rooms that De Los Santos says can process 50 to 100 horses a day.

    "It's complicated, this industry of feeding the world," Sarah De Los Santos says matter-of-factly. The meat would be processed for human consumption and exported to countries in eastern Europe and Asia.

    On Tuesday, the U.S. Department of Agriculture is scheduled to inspect the facility to decide whether it can become the first plant in the country to slaughter horses in more than six years.

    De Los Santos says he is not worried about passing the inspection. The plant passed one last year but then was told it couldn't begin operations until the USDA developed an acceptable test to measure the horse meat for drug residue.

    It wasn't until the plant sued the USDA for blocking its application that the agency earlier this year agreed to move forward with the inspections necessary to allow Valley Meat Co. and about a half-dozen other plants around the country to slaughter horses.

    The Obama administration wants to prohibit such slaughters. The administration's 2014 budget request excludes money for inspectors for horse slaughter plants, which would effectively keep them from operating.

    The USDA did not respond to an email from The Associated Press asking about the inspection process and whether a drug test has been developed.

    "Everyone is talking about this as a humane issue. This is not a humane issue. It's politics," said De Los Santos.

    Humane groups and politicians including Gov. Susana Martinez and New Mexico Attorney General Gary King strongly oppose the plant. They argue that horses are iconic animals in the West, and that other solutions and more funding for horse rescue and birth control programs should be explored over slaughter.

    Fueling opposition is a recent uproar in Europe over horse meat being found in products labeled as beef.

    Still others are pushing for a return to domestic slaughter. Proponents include several Native American tribes, the American Quarter Horse Association, some livestock associations and even a few horse rescue groups that believe domestic slaughter would be more humane than shipping the animals elsewhere.

    They point to a 2011 report from the U.S. Government Accountability Office that found horse abuse and abandonment increasing since Congress effectively banned horse slaughter by cutting funding for federal inspection programs in 2006. Because rescue groups can't take care of all of the horses in need, tens of thousands have been shipped to slaughterhouses in Mexico.

    In this mostly agricultural town, whose welcome sign touts it as the Dairy Capital of the Southwest, there is surprisingly little uproar over the plant.

    "I was against it," said Larry Connolly, a retiree having coffee at Starbucks last week. "Then I started talking to some ranchers. They said they were for it. So I'm neutral."

    Local horse trader and former rancher Dave McIntosh said opening the plant would be "the best thing for the welfare of horses."

    But Sheriff Rob Coon said he believes most people in town oppose the plant. His office was inundated with calls and emails from irate people after the horse-killing video was discovered online last month. The former Valley Meat worker posted the video more than a year ago in response to animal activists opposed to horse slaughter.

    "A lot the ranchers are for it, simply because they want a place to take a horse rather than starve it out," he said. "But it's not our society. We don't eat horses."

    Coon said his department has met with other local agencies in preparation for protests and potential trouble should the plant get the green light to open. But he clearly longs for the day when Roswell ? whose main street is populated with statues of green extraterrestrials ? was known for a rumored 1947 UFO landing, and little else.

    "I was just telling our county manager: What happened to our aliens?" Coon said.

    ___

    Follow Jeri Clausing at https://twitter.com/jericlausing

    Source: http://news.yahoo.com/nm-slaughterhouse-ground-zero-horse-debate-071837115.html

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    Study: Lax attitude on teens and Rx drug abuse

    WASHINGTON (AP) ? More parents need to talk with their teens about the dangers of abusing Ritalin, Adderall and other prescription drugs, suggests a new study that finds discouraging trends on kids and drug use.

    When teens were asked about the last substance abuse conversation they had with their parents, just 14 percent said they talked about abusing a prescription drug, said the report being released Tuesday by The Partnership at Drugfree.org.

    "For parents, it really comes down to not using the power they have because they don't think this is an immediate problem, meaning their own home, own neighborhood kind of thing," says Steve Pasierb, president of the partnership. "They believe that this is probably a safer way, not as bad as illegal street drugs."

    By comparison, most teens ? 81 percent ? said they have talked about the risks of marijuana use with their parents. Almost the same number said they have discussed alcohol with their parents. Almost one-third said they have talked about crack and cocaine.

    Some parents didn't see a significant risk in teens misusing prescription drugs.

    One in six parents said using prescription drugs to get high is safer than using street drugs, according to the survey. Almost one-third of the parents said attention deficit hyperactivity disorder (ADHD) medications such as Ritalin or Adderall can improve a child's academic or testing performance even if the teen does not have ADHD.

    For Tracey and Jeff Gerl, of Cypress, Texas, their son's drug abuse problem was a shock.

    "We just didn't know," said Jeff. He and his wife had the "drugs are bad" talk with their son, Nick, and thought he got the message. They called the parents of friends when he said he was spending the night to make sure an adult would be home. They tried to get to know his friends. Despite their efforts, Nick started smoking pot at the age of 12.

    In an AP interview, Nick said he and his friends often raided their parents' medicine cabinets for anything they could get their hands on ? codeine, Xanax, Ritalin. Some kids, Nick said, would have "skittles parties," where the teens threw all the pills they poached from home into a big bowl, mixed them up and then took a few without knowing exactly what they were ingesting.

    By 14, Nick's parents knew something was wrong. The day before he turned 15, they sent Nick to The Center for Success and Independence in Houston for 7 ? months of substance abuse treatment. It wasn't easy on anyone in the family ? Nick, his two younger brothers and his parents. Nick tried to escape twice, but made it through the program and has been sober now for a year.

    "My family life is a lot better. I'm realizing there are fun things in life that I can do sober," said Nick, now 16. "I got a chance to get clean and I have my whole life ahead of me."

    One in four teens in the study said they had misused or abused a prescription drug at least once. That's up sharply, a 33 percent increase, in the last five years. One in eight teens report misusing or abusing the drugs Ritalin or Adderall ? stimulants prescribed to treat ADHD. Other national studies also have seen a rise in abuse numbers for these stimulants among teens.

    The partnership's Pasierb says parents need to talk early and often with their children about the dangers of drugs, including prescription drugs. "They need to tell their children that this isn't healthy for you and it will break my heart if you do this."

    Looking back, Tracey Gerl says she should have listened to her gut more when she first suspected Nick might be using drugs.

    "If it doesn't seem right, it's not," said Gerl. "Don't ever be naive to think it's not my kid."

    For parents who want to clean out their medicine cabinets of old, unused or expired prescriptions ? the Drug Enforcement Administration and Justice Department is sponsoring a "take-back" day. Collection sites will be set up around the country on April 27 where people can safely toss away their unwanted medicine. Information about sites near you is available at: http://www.deadiversion.usdoj.gov/drug_disposal/takeback/ .

    The partnership's study was sponsored by the MetLife Foundation. Researchers surveyed 3,884 teens in grades 9-12 with anonymous questionnaires that the youngsters filled out at school from February to June 2012. The teen sample has a margin of error of plus or minus 2.1 percentage points. For the adults, the sample was 817 for surveying conducted from August to October 2012, with a margin of error of plus or minus 3.4 percentage points.

    Based in New York, The Partnership at Drugfree.org is formerly The Partnership for a Drug-Free America. The nonprofit group launched its new name in 2010 to position itself as more of a resource to parents and to avoid the misperception the partnership is a government organization.

    ___

    Online:

    Report will be available at 12:01 a.m. EDT: http://www.drugfree.org

    Source: http://news.yahoo.com/study-lax-attitude-teens-rx-drug-abuse-040237779.html

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    Tuesday, April 23, 2013

    New U.S. rocket blasts off from Virginia launch pad

    By Irene Klotz

    (Reuters) - A privately owned rocket built in partnership with NASA to haul cargo to the International Space Station blasted off on Sunday for a debut test flight from a new commercial spaceport in Virginia.

    The 13-story Antares rocket, developed and flown by Orbital Sciences Corp, lifted off at 5 p.m. EDT (2100 GMT) from a Virginia-owned and operated launch pad at NASA's Wallops Flight Facility on Wallops Island, Virginia.

    "Beautiful view," said NASA launch commentator Kyle Herring as live video from the rocket, broadcast on NASA TV, showed the booster riding atop a bright plume of fire above the Atlantic Ocean.

    Ten minutes later, the rocket deposited its payload - a 8,380-pound (3,800-kg) dummy capsule - into an orbit 158 miles above the planet, fulfilling the primary goal of the test flight.

    Orbital Sciences and privately owned Space Exploration Technologies, or SpaceX, hold NASA contracts worth a combined $3.5 billion to fly cargo to the space station, a $100 billion research outpost that flies about 250 miles above Earth.

    NASA turned to commercial suppliers after retiring the space shuttles in 2011.

    Flight controllers radioed news of Antares' successful debut to the station crew shortly after launch.

    "Wahoo, that's super," replied station commander Chris Hadfield, with the Canadian Space Agency.

    "Congratulations to all concerned. That bodes well for all of our futures," Hadfield said.

    On its next flight, scheduled for late June or early July, another Antares rocket will carry a Cygnus cargo ship on a demonstration mission to the station.

    California-based SpaceX completed three test flights and last year began delivering cargo to the station under its $1.6 billion contract.

    'A LONG SLOG'

    The debut of Orbital Sciences' Antares rocket was delayed by the construction of its launch pad at the Mid-Atlantic Regional Spaceport, located on the southern end of NASA's Wallops Island facility. Two launch attempts last week were canceled due to a last-minute technical problem followed by bad weather at the launch site.

    "It's been a long slog," NASA Administrator Charles Bolden said after the launch. "It's absolutely incredible what this team has done."

    NASA's share of developing the Antares rocket and Cygnus capsule will total about $288 million upon successful completion of the second and final planned test flight.

    Combined, NASA and Orbital Sciences spent about $300 million to develop Cygnus and slightly more than that to develop the rocket, Orbital Sciences Executive Vice President Frank Culbertson told reporters after the launch.

    "As a company it was a huge risk to invest in this," he said. "But I think it's going to demonstrate a commercial capability that will pay off in the long run."

    "With the right people pulling together and with great teammates, we were able to achieve this. We're real happy," Culbertson said.

    NASA's contribution to SpaceX's Falcon 9 rocket and Dragon cargo capsule development was $396 million.

    Standing 130 feet tall and packing 740,000 pounds of thrust at liftoff, Antares was the largest rocket to fly from Wallops Island, which has been operating for 68 years as a launch site for smaller suborbital rockets, high-altitude balloons and research aircraft.

    In addition to station cargo runs, Orbital Sciences has a separate contract to launch a NASA moon probe aboard a Minotaur 5 rocket from Wallops in August.

    (Reporting by Irene Klotz in Cape Canaveral, Florida; Editing by Eric Beech)

    Source: http://news.yahoo.com/u-rocket-blasts-off-virginia-launch-pad-002105502--finance.html

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    Uncleaned cells mean weak muscles

    Apr. 23, 2013 ? The protein complex mTORC1 promotes muscle growth. However, should this complex remain constantly active, it impairs the ability of the cells to self-clean, causing myopathy. Scientists working with Markus R?egg, Professor at the Biozentrum, University of Basel, describe the exact mechanism involved in the current issue of the scientific journal Cell Metabolism.

    Similarly to parts in a machine, individual components of a cell wear out with time. For a cell to remain healthy, malfunctioning components and waste products must be regularly disposed of or recycled. A cellular self-cleaning process, called autophagy, is responsible for this. However, the capacity for self-renewal decreases with age and participates in a wide range of age-related diseases such as cancer, heart disease and muscle weakness. In this process, the growth regulator, mTORC1, plays a primary role. The exact relationship has now been discovered by Markus R?egg's team from the Biozentrum of the University of Basel, together with scientists from the Department of Biomedicine.

    Muscle weakness due to overactive growth regulator

    Until recently, it was assumed that the protein complex mTORC1 in the skeletal muscle plays a key role in growth regulation but not in the process of autophagy. R?egg and his team of scientists have been able to refute this widely accepted assumption. In the current study, they investigated the cellular processes in skeletal muscle of mice, in which mTORC1 was permanently activated. Particularly in aging mice, the scientists observed a progressive myopathy, which could be ascribed to impaired autophagy. Interestingly, the researchers could reverse the symptoms by administering rapamycin. The muscle function of the mice returned to normal. Rapamycin is a substance that inhibits mTORC1, thereby promoting cell self-cleaning.

    Counteracting muscle breakdown

    According to these findings, mTORC1 plays a major role in tightly coordinating the mechanism of autophagy, maintaining the balance between muscle growth and breakdown. The scientists suspect that an overactive mTORC1 complex may also contribute to the development of the age-related muscle weakness seen in man. Therefore, a closer examination of the mTORC1 regulation system in the context of aging may provide new therapeutic approaches for the counteracting of the muscle weakness.

    Share this story on Facebook, Twitter, and Google:

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    Story Source:

    The above story is reprinted from materials provided by Universit?t Basel.

    Note: Materials may be edited for content and length. For further information, please contact the source cited above.


    Journal Reference:

    1. Perrine Castets, Shuo Lin, Nathalie Rion, Sabrina Di?Fulvio, Klaas Romanino, Maitea Guridi, Stephan Frank, Lionel?A. Tintignac, Michael Sinnreich, Markus?A. R?egg. Sustained Activation of mTORC1 in Skeletal Muscle Inhibits Constitutive and Starvation-Induced Autophagy and Causes a Severe, Late-Onset Myopathy. Cell Metabolism, 2013; DOI: 10.1016/j.cmet.2013.03.015

    Note: If no author is given, the source is cited instead.

    Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

    Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/R87ZMobNvdQ/130423091028.htm

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    'Voice' is dominated by art of the steal

    By Craig Berman

    ?The Voice? continued its battle rounds on Monday, and again much of the night was dominated by the steals, particularly Usher?s attempt to use them.

    Adam Rose/NBC

    Usher and Blake Shelton watch C. Perkins and Kris Thomas perform on "The Voice."

    Usher has had bad luck this season in failing to succeed in his attempts at thievery, and the show didn?t start off well for him when Luke Edgemon surprised the other coaches by giving Monique Abbadie all she could handle in a Team Shakira matchup and had the other three coaches salivating.

    ?What is not to like about Luke? He?s awesome,? Blake Shelton said. ?I thought Luke won that battle.?

    ?I thought he did too,? Adam Levine said.

    Trae Patton/NBC

    Shakira talks to Luke Edgemon and Monique Abbadie.

    If that was an attempt to use reverse psychology to get Shakira to keep Luke instead of a woman that all four coaches turned around for at the blind auditions, it didn?t work.

    ?I think I?m going to make a strategic decision, because I certainly hope you?re going to steal one of these two contestants,? Shakira said. ?Because you seemed so excited about Luke, I?m going to choose Monique.?

    Blake hit his button for the steal right away. Usher waited longer, but had a trump card to play as the only other coach besides Shakira to pick him at his audition. Surely that early love would be a big selling point.

    But put yourself in Luke?s shoes.? When you hear the following sales pitches:

    Blake: ?What is it not about Luke? Are you kidding me? He?s awesome.? That was one of the most energetic, pitch-perfect performances in the battle rounds that I?ve seen in a long time. It was amazing.?

    Followed by Usher:? ?I think that, you know?

    [five-second pause, broken by Blake saying, ?Well that?s a good point.?]

    Usher (continued): ??You know, I really feel like Luke did an incredible job, and given the fact that I pushed my button the first time ? the decision is up to you.?

    Who would you have picked?

    Not surprisingly, Luke went for the coach who seemed to really want him over the one who kinda sorta liked him, or maybe just had those two steals burning a hole in his pocket.

    Usher did finally succeed on stealing someone from Team Shakira later in the show, but even that was dramatic.? After? C. Perkins lost his battle to Kris Thomas, the coach was silent until he walking off the stage shaking everyone?s hands. Just as he reached Usher?s chair and reached out to shake hands, Usher pushed his button.

    ?I really feel like he has talent that we have yet to see, and I let him sit in it a little bit so he?d be reminded what it feels like to not have it, so he?ll never take it for granted.? Usher said.

    Nor will he take his heart beating for granted after that scare.

    Adam also got into the act, nabbing? Orlando Dixon from Usher. So if you?re keeping track, only Usher has a steal left heading into Tuesday?s battle round finale. ?At least that means he can?t lose another popularity contest.?

    Related content:

    Source: http://theclicker.today.com/_news/2013/04/22/17868240-voice-is-dominated-by-art-of-the-steal?lite

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